Please use this identifier to cite or link to this item: http://hdl.handle.net/2307/322
Title: Covalent surface modification of titanium oxide with different adhesive peptides: Surface characterization and osteoblast-like cell adhesion
Authors: Dettin, Monica
Bagno, Andrea
Gambaretto, Roberta
Iucci, Giovanna
Conconi, Maria Teresa
Tuccitto, Nunzio
Menti, Anna Michela
Grandi, Claudio
Di Bello, Carlo
Licciardello, Antonino
Polzonetti, Giovanni
Keywords: CHEMICAL-MODIFICATION
IN-VITRO
ATTACHMENT
RGD
BIOMATERIALS
FILM
Issue Date: Jul-2009
Publisher: Wiley-Liss
Abstract: A fundamental goal in the field of implantology is the design of innovative devices suitable for promoting, implant-to-tissue integration. This result can be achieved by means of surface modifications aimed at optimizing tissue regeneration. In the framework of oral and orthopedic implantology, surface modifications concern both the optimization of titanium/titanium alloy surface roughness and the attachment of biochemical factors able to guide cellular adhesionand/or growth. This article focuses on the covalent attachment of two different adhesive peptides to rough titanium disks. The capability of biomimetic surfaces to increase osteoblast adhesion and the specificity of their biological activity due to the presence of cell adhesion signal-motif have also been investigated. In addition, surface analyses by profilometry, X-ray photoelectron spectroscopy, and time of flight-secondary ion mass spectrometry have been carried out to investigate the effects and modifications induced by grafting procedures. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 90A:35-45, 2009
URI: http://hdl.handle.net/2307/322
ISSN: 1549-3296
DOI: 10.1002/jbm.a.32064
Appears in Collections:A - Articolo su rivista
X_Dipartimento di Fisica 'Edoardo Amaldi'

Files in This Item:
File Description SizeFormat Existing users please Login
JBiomedMatRes09a.pdf456.99 kBAdobe PDF    Request a copy
SFX Query Show full item record Recommend this item

Page view(s)

1
Last Week
0
Last month
0
checked on Aug 11, 2020

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.