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Title: | Quantum Behavior of Water Protons in Protein Hydration Shell | Authors: | Pagnotta, S. E. Bruni, Fabio Senesi, R. Pietropaolo, A. |
Keywords: | INELASTIC NEUTRON-SCATTERING ENZYME CATALYSIS HYDROGEN-BONDS DYNAMICS TRANSITION TIME FLUCTUATIONS DEPENDENCE LYSOZYME SOLVENT |
Issue Date: | Mar-2009 | Publisher: | Elsevier (Cell Press) | Abstract: | Quantum effects on the water proton dynamics over the surface of ahydrated protein are measured by means of broadband dielectricspectroscopy and deep inelastic neutron scattering. Dielectricspectroscopy indicates a reduced energy barrier for a hydrogenatedprotein sample compared to a deuterated one, along with a large andtemperature-dependent isotopic ratio, in good agreement withtheoretical studies. Recent deep inelastic neutron scattering data havebeen reanalyzed, and now show that the momentum distribution of waterprotons reflects a characteristic delocalization at ambienttemperatures. These experimental findings might have far-reachingimplications for enzymatic catalysis involving proton transferprocesses, as in the case of the lysozyme protein studied in thisreport. | URI: | http://hdl.handle.net/2307/383 | ISSN: | 0006-3495 | DOI: | 10.1016/j.bpj.2008.10.062 |
Appears in Collections: | A - Articolo su rivista X_Dipartimento di Fisica 'Edoardo Amaldi' |
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